Generalized Anxiety Disorder (GAD)
Anxiety is excessive, distressing, and impairing
Most patients report a lifelong history of anxiety (history of chronic anxiety predating the onset of recent stressors).
Typically, patients experience worsening symptoms during periods of increased stress.
Generalized anxiety disorder is characterized by excessive, uncontrollable anxiety about multiple issues, found in conjunction with 3+ of the following symptoms for at least the last 6 months:
First-line treatment options for GAD include:
Pharmacotherapy with SSRIs or SNRIs
Buspirone is a second-line agent and anxiolytic used in the treatment of GAD. Its mechanism of action is unknown, but it is known to have high affinity for the 5-HT1A and 5-HT2 receptors, as well as moderate affinity for D2 receptors.